يجب عدم تطبيق الدواء لدى مرضى القصور الكبدي الشديد. يجب إنقاص الجرعة بمقدار النصف لدى مرضى القصور الكبدي البسيط إلى متوسط الشدة.aA TEAE was outlined as an adverse celebration developing all through or just after study drug administration and up
Beneath the necessities on the REMS, drug corporations with authorised opioid analgesic products will have to make REMS-compliant education schemes accessible to Health care suppliers. Healthcare suppliers are strongly encouraged toRecommend patients to seek medical consideration should they knowledge a constellation of such symptoms [see WARNINGS]